Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: comparison with effect of disopyramide.

@article{Wu1994MolecularMO,
  title={Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: comparison with effect of disopyramide.},
  author={Sergio N Wu and Tadashi Nakajima and Toru Yamashita and E. 2. Hamada and Hiroaki Hazama and Kuniaki Iwasawa and Masao Omata and Yoshihisa Kurachi},
  journal={Journal of cardiovascular pharmacology},
  year={1994},
  volume={23 4},
  pages={618-23}
}
The anticholinergic effects of cibenzoline were examined and compared with those of disopyramide in atrial myocytes isolated from guinea pig heart. The tight-seal whole-cell voltage clamp technique was performed with a patch pipette filled with guanosine-5'-triphosphate (GTP) or guanosine-5'-O-(3-thiotriphosphate) (GTP gamma S). In GTP-loaded cells, both acetylcholine (ACh) and adenosine (Ado) induced a specific K channel current through GTP-binding proteins by binding to the muscarinic and Ado… CONTINUE READING