Molecular mechanism of active Ca2+ reabsorption in the distal nephron.

  title={Molecular mechanism of active Ca2+ reabsorption in the distal nephron.},
  author={Joost G. J. Hoenderop and Bernd Nilius and Ren{\'e} J M Bindels},
  journal={Annual review of physiology},
The identification of the epithelial Ca(2+) channel (ECaC) complements the group of Ca(2+) transport proteins including calbindin-D28K, Na(+)/Ca(2+) exchanger and plasma membrane Ca(2+)-ATPase, which are co-expressed in 1,25(OH)2D3- responsive nephron segments. ECaC constitutes the rate-limiting apical entry step in the process of active transcellular Ca(2+) transport and belongs to a superfamily of Ca(2+) channels that includes the vanilloid receptor and transient receptor potential channels… CONTINUE READING
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