Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.

  title={Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.},
  author={Feng Qiu and Adam C Chamberlin and Briana M Watkins and Alina Ionescu and Marta Elena Perez and Ren{\'e} Barro-Soria and Carlos G. Gonz{\'a}lez and Sergei Yu Noskov and Hans Peter Larsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 40},
Voltage-gated proton (Hv1) channels are involved in many physiological processes, such as pH homeostasis and the innate immune response. Zn2+ is an important physiological inhibitor of Hv1. Sperm cells are quiescent in the male reproductive system due to Zn2+ inhibition of Hv1 channels, but become active once introduced into the low-Zn2+-concentration environment of the female reproductive tract. How Zn2+ inhibits Hv1 is not completely understood. In this study, we use the voltage clamp… CONTINUE READING
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