Molecular mechanism of S-modulin action: binding target and effect of ATP.

Abstract

S-Modulin is suggested to increase the light sensitivity of rods by inhibiting phosphorylation of light-activated rhodopsin (Rh*) at high Ca2+ concentrations. The inhibition of rhodopsin phosphorylation was almost constant over a wide range of the Rh*/S-modulin ratio (10(-4)-approximately 10[1]). A 125I-labeled cross-linker that had been conjugated with S… (More)

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