Molecular mechanism of PPAR in the regulation of age-related inflammation.

  title={Molecular mechanism of PPAR in the regulation of age-related inflammation.},
  author={Jae Heun Chung and Arnold Young Seo and Sang Woon Chung and Mi Kyung Kim and Christiaan Leeuwenburgh and Byung Pal Yu and Hae Young Chung},
  journal={Ageing research reviews},
  volume={7 2},
Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the… CONTINUE READING
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