Molecular mechanism of Aspergillus fumigatus adherence to host constituents.

@article{Sheppard2011MolecularMO,
  title={Molecular mechanism of Aspergillus fumigatus adherence to host constituents.},
  author={Donald C Sheppard},
  journal={Current opinion in microbiology},
  year={2011},
  volume={14 4},
  pages={375-9}
}
Inhaled conidia of Aspergillus fumigatus rapidly adhere to pulmonary epithelial cells and other host constituents. Identifying molecular mechanisms underlying A. fumigatus adherence has therefore been the focus of a number of studies aimed at identifying novel therapeutic targets. Early studies of A. fumigatus adherence to host constituents focused on fungal proteins, including RodA and AspF2. None of these proteins however has been found to play a role in virulence in experimental animal… CONTINUE READING