Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation.

@article{Ochiai2008MolecularMF,
  title={Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation.},
  author={Takashi Ochiai and Yuka Takenaka and Yukako Kuramoto and Masakazu Kasuya and Kanemasa Fukuda and Masahiko Kimura and Hiroshi Shimeno and Roberta Misasi and Masao Hiraiwa and Shinji Soeda},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1780 12},
  pages={1441-7}
}
Prosaposin triggers G-protein-coupled receptor (GPCR)-mediated protein kinase B (Akt)/extracellular signal-regulated kinase (ERK) phosphorylation cascades to exert its neurotrophic and myelinotrophic activity capable of preventing neural cell death and promoting neural proliferation and glial differentiation. In the present study, we investigated the down-stream neurotrophic signaling mechanism of prosaposin by which rat pheochromocytoma (PC-12) cells are protected from cell death induced by… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 2013
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