Molecular mechanism for activation of superoxide-producing NADPH oxidases.

  title={Molecular mechanism for activation of superoxide-producing NADPH oxidases.},
  author={Ryu Takeya and Hideki Sumimoto},
  journal={Molecules and cells},
  volume={16 3},
The membrane-integrated protein gp91phox, existing as a heterodimer with p22phox, functions as the catalytic core of the phagocyte NADPH oxidase, which plays a crucial role in host defence. The oxidase, dormant in resting cells, becomes activated to produce superoxide, a precursor of microbicidal oxidants, by interacting with the adaptor proteins p47phox and p67phox as well as the small GTPase Rac. In the past few years, several proteins homologous to gp91phox were discovered as superoxide… CONTINUE READING
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