Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor.

@article{Yamada2003MolecularMA,
  title={Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor.},
  author={Motoko Yamada and Shokei Kim and Kensuke Egashira and Motohiro Takeya and Tomohiro Ikeda and Osamu Mimura and Hiroshi Iwao},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 11},
  pages={1996-2001}
}
OBJECTIVE We investigated the role of monocyte chemoattractant protein-1 (MCP-1) in vascular endothelial growth factor (VEGF)-induced angiogenesis and vascular permeability and the underlying molecular mechanism of VEGF-induced endothelial MCP-1 expression in vitro and in vivo. METHODS AND RESULTS We used an anti-MCP-1 neutralizing antibody for specific inhibition of MCP-1. VEGF increased tubule formation in the angiogenesis assay and vascular permeability in the Miles assay, and these… CONTINUE READING