Molecular markers reveal cryptic sex in the human pathogen Coccidioides immitis.

@article{Burt1996MolecularMR,
  title={Molecular markers reveal cryptic sex in the human pathogen Coccidioides immitis.},
  author={Austin Burt and Deidre A Carter and Gina L. Koenig and Thomas J. White and John W Taylor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 2},
  pages={770-3}
}
Coccidioides immitis, cause of a recent epidemic of "Valley fever" in California, is typical of many eukaryotic microbes in that mating and meiosis have yet to be reported, but it is not clear whether sex is truly absent or just cryptic. To find out, we have undertaken a population genetic study using PCR amplification, screening for single-strand conformation polymorphisms, and direct DNA sequencing to find molecular markers with nucleotide-level resolution. Both population genetic and… CONTINUE READING
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