Molecular markers of hemostatic activation and inflammation following major injury: effect of therapy with IFN-gamma.

@article{Dries1998MolecularMO,
  title={Molecular markers of hemostatic activation and inflammation following major injury: effect of therapy with IFN-gamma.},
  author={David J. Dries and Jeanine M. Walenga and Debra A. Hoppensteadt and Jawed Fareed},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1998},
  volume={18 5},
  pages={
          327-35
        }
}
Interferon-gamma (IFN-gamma) has shown promise in treatment of injured patients. However, reactive states marked by immunologic and inflammatory responses constitute a potential deleterious effect of IFN-gamma administration. IFN-gamma therapy has been associated with high levels of tumor necrosis factor-alpha (TNF-alpha), with potential enhancement of coagulopathy after injury. This study evaluated TNF-alpha production and markers of hemostatic activation in patients receiving IFN-gamma… CONTINUE READING
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