Molecular markers of extracellular matrix remodeling in glioblastoma vessels: microarray study of laser-captured glioblastoma vessels.

@article{Pen2007MolecularMO,
  title={Molecular markers of extracellular matrix remodeling in glioblastoma vessels: microarray study of laser-captured glioblastoma vessels.},
  author={Ally Pen and Mari{\'a} Jes{\'u}s Moreno and Joel H. Martin and Danica B. Stanimirovi{\'c}},
  journal={Glia},
  year={2007},
  volume={55 6},
  pages={559-72}
}
Glioblastoma multiforme (GBM) are the most malignant and vascularized brain tumors. The aberrant vascular phenotype of GBM could be exploited for diagnosis or therapeutic targeting. This study identified new molecular markers of GBM vessels, using a combination of laser capture microdissection (LCM) microscopy, RNA amplification, and microarray analyses to compare vessels from nonmalignant human brain and GBM tumors. Forty-two genes were differentially expressed in GBM vessels compared to… CONTINUE READING