Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.

@article{Rosell2002MolecularMA,
  title={Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.},
  author={Rafael Rosell and Frank V. Fossella and Luka Milas},
  journal={Lung cancer},
  year={2002},
  volume={38 Suppl 4},
  pages={43-9}
}
Detection of genomic differences predictive of drug response or resistance in individual patients may allow therapy to be customized to the characteristics of particular tumors. Preliminary findings are that non-small cell lung cancer patients overexpressing ERCC1 mRNA have lower response to cisplatin chemotherapy, while those overexpressing ribonucleotide reductase mRNA have limited benefit from gemcitabine. In addition, overexpression of beta-tubulin III and stathmin can influence the… CONTINUE READING
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