Molecular markers and genetics in cancer development.

  title={Molecular markers and genetics in cancer development.},
  author={Kathy Hormi-Carver and Rhonda F Souza},
  journal={Surgical oncology clinics of North America},
  volume={18 3},
This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.