Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies.

@article{Lin1999MolecularMO,
  title={Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies.},
  author={M S Lin and M. A. Gharia and Chang Ling Fu and Monica Olague-Marchan and Miles P. Hacker and Karen E Harman and Balbir S. Bhogal and Mark M. Black and Luis A Diaz and George J. Giudice},
  journal={Clinical immunology},
  year={1999},
  volume={92 3},
  pages={285-92}
}
Herpes gestationis (HG) is an autoantibody-mediated subepidermal bullous dermatosis associated with pregnancy. The primary target of HG autoantibodies is BP180, a 180-kDa hemidesmosomal glycoprotein. We previously showed that autoantibodies and autoimmune T lymphocytes from HG patients recognize the MCW-1 antigenic site (AA 507-520), which is located in the membrane-proximal noncollagenous domain (NC16A) of BP180. Here, we analyzed the sera of 37 HG patients to further define the sites on BP180… CONTINUE READING