Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

@article{Dunham1987MolecularMO,
  title={Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.},
  author={Ian Dunham and Carole A. Sargent and John Trowsdale and Robert D. Campbell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 20},
  pages={7237-41}
}
Pulsed-field gel electrophoresis and "cosmid walking" have been used to establish a molecular map of the human major histocompatibility complex (MHC). We have isolated approximately equal to 230 kilobases (kb) of genomic DNA in overlapping cosmid clones covering the genes for the second and fourth components of complement (C2 and C4, respectively), factor B, and steroid 21-hydroxylase, and approximately equal to 82 kb of genomic DNA surrounding the genes for the tumor necrosis factors alpha and… CONTINUE READING

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