Molecular mapping of general anesthetic sites in a voltage-gated ion channel.

@article{Barber2011MolecularMO,
  title={Molecular mapping of general anesthetic sites in a voltage-gated ion channel.},
  author={Annika F. Barber and Qiansheng Liang and Cristiano Torres do Amaral and Werner Treptow and Manuel Covarrubias},
  journal={Biophysical journal},
  year={2011},
  volume={101 7},
  pages={1613-22}
}
Several voltage-gated ion channels are modulated by clinically relevant doses of general anesthetics. However, the structural basis of this modulation is not well understood. Previous work suggested that n-alcohols and inhaled anesthetics stabilize the closed state of the Shaw2 voltage-gated (Kv) channel (K-Shaw2) by directly interacting with a discrete channel site. We hypothesize that the inhibition of K-Shaw2 channels by general anesthetics is governed by interactions between binding and… CONTINUE READING

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