Molecular manipulations of the multidrug transporter: a new role for transgenic mice.

  title={Molecular manipulations of the multidrug transporter: a new role for transgenic mice.},
  author={Ira Pastan and Mark C. Willingham and Michael M. Gottesman},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={5 11},
Multidrug resistance in human cancer is associated with overexpression of the MDR1 gene which encodes a 170,000 molecular weight membrane glycoprotein that transports cytotoxic drugs out of cancer cells. The MDR1 gene is normally expressed in intestine, kidney, liver, and adrenal glands, and in tumors derived from these tissues, but it is not expressed in normal bone marrow. Transgenic mice that express the MDR1 gene in their bone marrow have been developed, and because of this expression these… CONTINUE READING


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