Molecular magnetic resonance imaging of coronary thrombosis and pulmonary emboli with a novel fibrin-targeted contrast agent.

@article{Spuentrup2005MolecularMR,
  title={Molecular magnetic resonance imaging of coronary thrombosis and pulmonary emboli with a novel fibrin-targeted contrast agent.},
  author={Elmar Spuentrup and Arno B{\"u}cker and Marcus Katoh and Andrea J. Wiethoff and Edward C Parsons and Ren{\'e} M. Botnar and Robert M. Weisskoff and Philip B Graham and Warren J. Manning and Rolf W. G{\"u}nther},
  journal={Circulation},
  year={2005},
  volume={111 11},
  pages={1377-82}
}
BACKGROUND The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include coronary thrombosis or pulmonary emboli. The aim of this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging of coronary thrombosis and pulmonary emboli. METHODS AND RESULTS Fresh clots were engineered ex vivo from human blood and delivered in the lungs and coronary arteries of 7 swine. Subsequent… CONTINUE READING

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