Molecular machines for protein degradation.

  title={Molecular machines for protein degradation.},
  author={Michael Groll and Matthias Bochtler and Katharina H{\"a}ussermann and Tim Clausen and Robert Huber},
  journal={Chembiochem : a European journal of chemical biology},
  volume={6 2},
One of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome-related protein-degradation machineries, like HslVU in eubacteria. Peptides generated by proteasomes and related systems can be used by the cell, for example, for antigen presentation. However, most of the peptides must be degraded to single… CONTINUE READING

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