Molecular lymphangiogenesis: new players.

  title={Molecular lymphangiogenesis: new players.},
  author={Tuomas Tammela and Tatiana V Petrova and Kari Alitalo},
  journal={Trends in cell biology},
  volume={15 8},
The function of the lymphatic vascular system as a conduit for immune cells and excess tissue fluid has been known for over a century, but the molecular players involved in lymphangiogenesis--the formation of lymphatic vessels--have remained unknown until recently. Signals mediated by vascular endothelial growth factor-C, the homeodomain transcription factor PROX1 and the forkhead transcription factor FOXC2 have been implicated in the growth, morphogenesis and hierarchic organization of the… CONTINUE READING


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