Molecular link between dietary fibre, gut microbiota and health

  title={Molecular link between dietary fibre, gut microbiota and health},
  author={Jitendra Kumar and Kavita Rani and Chander Datt},
  journal={Molecular Biology Reports},
  pages={1 - 9}
Natural polysaccharides cellulose, hemicelluloses, inulin etc., galactooligosaccharides (GOS), and fructooligosaccharides (FOS) play a significant role in the improvement of gut microbiota balance and human health. These polysaccharides prevent pathogen adhesion that stimulates the immune system and gut barrier function by servicing as fermentable substrates for the gut microbiota. The gut microbiota plays a key role in the fermentation of non-digestible carbohydrates (NDCs) fibres. Moreover… 

Signaling Pathways Associated with Metabolites of Dietary Fibers Link to Host Health

This chapter will focus on dietary fibers, which interact directly with gut microbes and lead to the production of metabolites and discuss how dietary fiber impacts gut microbiota ecology, host physiology, and health and molecule mechanism of dietary fiber on signaling pathway that linked to the host health.

Biological Function of Short-Chain Fatty Acids and Its Regulation on Intestinal Health of Poultry

There may be an optimal level and proportion of SCFAs in poultry intestine, which benefits to gut health of poultry, as well as nutritional strategies to regulate SCFA production in the poultry gut.


This review has collected data from a key metabolites generated by the microbiota, the short chain fatty acids (SCFAs), showing that they are capable of modifying the physiology of the host at different levels: appetite regulation, glucose homeostasis, lipid metabolism, gut integrity and anti-oxidative, anti-inflammatory and immuno-modulatory effects.

Modulating the Gut Microbiota of Humans by Dietary Intervention with Plant Glycans

  • G. Tannock
  • Biology
    Applied and Environmental Microbiology
  • 2020
It is concluded that research should aim at improving knowledge of bacterial consortia that, through shared nourishment, degrade and ferment plant glycans that boost functional resilience and correction of dysbiosis.

Relandscaping the Gut Microbiota with a Whole Food: Dose–Response Effects to Common Bean

Investigation of the origins of the dose dependent and biological sex differences in response to common bean consumption may provide insights into bean-gut microbiota-host interactions important to developing food-based precision approaches to chronic disease prevention and control.

Health benefits of edible mushroom polysaccharides and associated gut microbiota regulation

It is concluded that EMPs can be considered a dietary source for the improvement and prevention of several health risks, and the theoretical basis and technical guidance for the development of novel functional foods with the utilization of edible mushrooms are provided.

High-Salt Diet Induces Depletion of Lactic Acid-Producing Bacteria in Murine Gut

The presented data show that HSD cause disturbances in the ecological balance of the gastrointestinal microflora primarily through depletion of lactic acid-producing bacteria in a dose-dependent manner and may have important implications for salt-sensitive inflammatory diseases.

Modulation of gut microbiota and fecal metabolites by corn silk among high-fat diet-induced hypercholesterolemia mice

The present study indicates that the modifications in the gut microbiota and subsequent host bile acid metabolism may be a potential mechanism for the antihypercholesterolemic effects of CS extract.

Crosstalk between traditional Chinese medicine-derived polysaccharides and the gut microbiota: A new perspective to understand traditional Chinese medicine.

The extraction and pharmacological effects of TCM polysaccharides, various functions of the gut microbiota, and the interactions between TCM Polysaccharide and the Gut microbiota are discussed, illuminating the mechanisms of TCm poly Saccharides modulating host physiology via the gut microbiome.



Dietary fiber and prebiotics and the gastrointestinal microbiota

The current knowledge of the impact of fiber and prebiotic consumption on the composition and metabolic function of the human gastrointestinal microbiota is reviewed, including the effects of physiochemical properties of complex carbohydrates, adequate intake and treatment dosages, and the phenotypic responses related to the composition of thehuman microbiota.

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

It is found that adopting a high-fiber diet promoted the growth of SCFA-producing organisms in diabetic humans and had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production.

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids.

Gut-derived acetate, propionate, and butyrate play important roles as substrates for glucose, cholesterol, and lipid metabolism and microarray data suggested that SCFAs exert a mild regulatory effect on the expression of genes involved in hepatic metabolic pathways during the 6-h infusion period.

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals.

Twelve-week supplementation of GOS selectively increased fecal Bifidobacterium species abundance, but this did not produce significant changes in insulin sensitivity or related substrate and energy metabolism in overweight or obese prediabetic men and women.

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

These results reveal that not all fermentable fibers are equally capable of stimulating SCFA production, and they highlight the importance of the composition of an individual’s microbiota in

Altered short chain fatty acid profiles induced by dietary fiber intervention regulate AMPK levels and intestinal homeostasis.

The results suggested a new regulatory mechanism via which butanoate and AMPK activation contributed to intestinal integrity and homeostasis by affecting metabolism, intestinal barrier function and transporter expression.

The role of short chain fatty acids in appetite regulation and energy homeostasis

An overarching model for the effects of SCFAs on one of their beneficial aspects: appetite regulation and energy homeostasis is suggested.

Microbial degradation of complex carbohydrates in the gut

The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.

Regulation of short-chain fatty acid production

Chemostat studies using pure cultures of saccharolytic gut micro-organisms demonstrate that C availability and growth rate strongly affect the outcome of fermentation, which can be seen through the effects of inorganic electron acceptors on fermentation processes.