Molecular link between cholesterol, cytokines and atherosclerosis

  title={Molecular link between cholesterol, cytokines and atherosclerosis},
  author={Deepak Kaul},
  journal={Molecular and Cellular Biochemistry},
Current investigation on the origin of atherosclerosis has initiated an intense debate over whether atherosclerosis results from hypercholesterolemia or an inappropriate immune response to vascular injury. Although the role of the immune system has been questioned, the overwhelming body of evidence clearly indicates that atherogenesis is initiated by the interplay between cholesterol and cellular secretion of cytokines (especially IL-6) and apolipoprotein ‘E’ within the arterial wall. Recent… CONTINUE READING