Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides

@inproceedings{Zitnay2017MolecularLD,
  title={Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides},
  author={Jared L. Zitnay and Yang Li and Zhao Qin Qin and Boi Hoa San and Baptiste Depalle and Shawn Peter Reese and Markus J Buehler and S Michael Yu and Jeffrey A. Weiss},
  booktitle={Nature communications},
  year={2017}
}
Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in pathological processes. Here, we utilize collagen hybridizing peptide (CHP), which binds unfolded collagen by triple helix formation, to detect molecular level subfailure damage to… CONTINUE READING
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