Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays

@article{Midorikawa2006MolecularKO,
  title={Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays},
  author={Yutaka Midorikawa and Shunsuke Yamamoto and Susumu Ishikawa and Naoko Kamimura and Hisaki Igarashi and Haruhiko Sugimura and Masatoshi Makuuchi and Hiroyuki Aburatani},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={5581-5590}
}
Genomic amplification of oncogenes and inactivation of suppressor genes are critical in the pathogenesis of human cancer. To identify chromosomal alterations associated with hepatocarcinogenesis, we performed allelic gene dosage analysis on 36 hepatocellular carcinomas (HCCs). Data from high-density single-nucleotide polymorphism arrays were analysed using the Genome Imbalance Map (GIM) algorithm, which simultaneously detects DNA copy number alterations and loss of heterozygosity (LOH) events… CONTINUE READING

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Cancer Res 64: 3060–3071

X Zhao, C Li, +3 authors TH Chen
Supplementary Information accompanies the paper on the Oncogene website (http://www.nature.com/onc). • 2004
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