Molecular karyotyping: array CGH quality criteria for constitutional genetic diagnosis.

@article{Vermeesch2005MolecularKA,
  title={Molecular karyotyping: array CGH quality criteria for constitutional genetic diagnosis.},
  author={Joris Robert Vermeesch and Cindy Melotte and G Froyen and Steven Van Vooren and Binita Dutta and N Eline Maas and Stefan Vermeulen and Bj{\"o}rn Menten and Frank Speleman and B De Moor and Paul van Hummelen and Peter Marynen and J E Fryns and Koenraad Devriendt},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2005},
  volume={53 3},
  pages={413-22}
}
Array CGH (comparative genomic hybridization) enables the identification of chromosomal copy number changes. The availability of clone sets covering the human genome opens the possibility for the widespread use of array CGH for both research and diagnostic purposes. In this manuscript we report on the parameters that were critical for successful implementation of the technology, assess quality criteria, and discuss the potential benefits and pitfalls of the technology for improved pre- and… CONTINUE READING