Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidine-rich protein genes.

@article{Kemp1987MolecularKO,
  title={Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidine-rich protein genes.},
  author={David J. Kemp and Jennifer K. Thompson and David Walliker and Lynn M Corcoran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 21},
  pages={7672-6}
}
We describe fractionation of the Plasmodium falciparum genome into 14 chromosomal DNA molecules by pulsed-field gel electrophoresis. This number agrees with the number of chromosomes observed by electron microscopic visualization of kinetochores. The assignment of 25 markers to 12 of the 14 chromosomes in three cloned parasite lines demonstrates that chromosomal size variation can greatly change the relative migration of genetically equivalent chromosomes. Deletions that include genes for three… CONTINUE READING