Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

@article{Brossier2011MolecularIO,
  title={Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.},
  author={Florence Brossier and Nicolas Veziris and Chantal Truffot-Pernot and Vincent Jarlier and Wladimir Sougakoff},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 1},
  pages={355-60}
}
Ethionamide (ETH) needs to be activated by the mono-oxygenase EthA, which is regulated by EthR, in order to be active against Mycobacterium tuberculosis. The activated drug targets the enzyme InhA, which is involved in cell wall biosynthesis. Resistance to ETH has been reported to result from various mechanisms, including mutations altering EthA/EthR, InhA and its promoter, the NADH dehydrogenase encoded by ndh, and the MshA enzyme, involved in mycothiol biosynthesis. We searched for such… CONTINUE READING

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