Molecular interplay between the replicative helicase DnaC and its loader protein DnaI from Geobacillus kaustophilus.

@article{Tsai2009MolecularIB,
  title={Molecular interplay between the replicative helicase DnaC and its loader protein DnaI from Geobacillus kaustophilus.},
  author={Kuang-Lei Tsai and Yu-Hua Lo and Yuh-Ju Sun and C. Hsiao},
  journal={Journal of molecular biology},
  year={2009},
  volume={393 5},
  pages={1056-69}
}
Helicase loading factors are thought to transfer the hexameric ring-shaped helicases onto the replication fork during DNA replication. However, the mechanism of helicase transfer onto DNA remains unclear. In Bacillus subtilis, the protein DnaI, which belongs to the AAA+ family of ATPases, is responsible for delivering the hexameric helicase DnaC onto DNA. Here we investigated the interaction between DnaC and DnaI from Geobacillus kaustophilus HTA426 (GkDnaC and GkDnaI, respectively) and… CONTINUE READING

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