Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells.

@article{Gulappa2013MolecularIB,
  title={Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells.},
  author={Thippeswamy Gulappa and Ramadevi Subramani Reddy and Suman Suman and Alice M. Nyakeriga and Chendil Damodaran},
  journal={Cancer letters},
  year={2013},
  volume={337 2},
  pages={177-83}
}
This study examined the effect of 3, 9-dihydroxy-2-prenylcoumestan (pso), a furanocoumarin, on PC-3 and C4-2B castration-resistant prostate cancer (CRPC) cell lines. Pso caused significant G0/G1 cell cycle arrest and inhibition of cell growth. Molecular analysis of cyclin (D1, D2, D3, and E), cyclin-dependent kinase (cdk) (cdks 2, 4, and 6), and cdk… CONTINUE READING