Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis

@article{LpezVicario2013MolecularIB,
  title={Molecular interplay between $\Delta$5/$\Delta$6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis},
  author={C. L{\'o}pez-Vicario and A. Gonz{\'a}lez‐P{\'e}riz and Bibiana Rius and Eva Mor{\'a}n‐Salvador and Ver{\'o}nica Garc{\'i}a-Alonso and J. Lozano and R. Bataller and M. Cof{\'a}n and J. Kang and V. Arroyo and J. Cl{\`a}ria and E. Titos},
  journal={Gut},
  year={2013},
  volume={63},
  pages={344 - 355}
}
Objective The mechanisms underlying non-alcoholic steatohepatitis (NASH) are not completely elucidated. In the current study we integrated gene expression profiling of liver biopsies from NASH patients with translational studies in mouse models of steatohepatitis and pharmacological interventions in isolated hepatocytes to identify new molecular targets in NASH. Design and results Using oligonucleotide microarray analysis we identified a significant enrichment of genes involved in the multi… Expand
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