Molecular interactions that confer latency to transforming growth factor-beta.

  title={Molecular interactions that confer latency to transforming growth factor-beta.},
  author={Geoffrey D. Young and Joanne E Murphy-Ullrich},
  journal={The Journal of biological chemistry},
  volume={279 36},
A major point of regulation of transforming growth factor-beta (TGF-beta) function is through control of activation of the latent TGF-beta complex, which consists of the latency associated peptide (LAP) secreted in non-covalent association with mature TGF-beta. Activation involves proteolysis, dissociation, or altered binding of LAP. However, the mechanism by which LAP confers latency to TGF-beta is poorly understood. Previously, we identified a conserved sequence near the N terminus of LAP as… CONTINUE READING


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