Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer

  title={Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer},
  author={C. Drewniok and B. G. Wienrich and M. Sch{\"o}n and J. Ulrich and Q. Zen and Marilyn J. Telen and R. Hartig and I. Wieland and H. Gollnick},
  journal={Archives of Dermatological Research},
  • C. Drewniok, B. G. Wienrich, +7 authors M. Schön
  • Published 2004
  • Biology, Medicine
  • Archives of Dermatological Research
  • Molecular events underlying the progression of malignant tumors through the surrounding tissue are largely mediated by membrane-bound adhesion molecules. Basal-cell adhesion molecule (B-CAM), a 90-kDa laminin receptor of the immunoglobulin superfamily, is induced in some epithelial malignancies. Its function in these tumors, however, still remains obscure. We demonstrated that expression of B-CAM is very weak, if detectable at all, in normal epidermis but is strongly induced in both basal cell… CONTINUE READING
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