Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.

@article{Yu2013MolecularIO,
  title={Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.},
  author={Xiang Yu and Qiuming Wang and Qingfen Pan and Feimeng Zhou and Jie Zheng},
  journal={Physical chemistry chemical physics : PCCP},
  year={2013},
  volume={15 23},
  pages={8878-89}
}
Interaction of p3 (Aβ(17-42)) peptides with cell membranes is crucial for the understanding of amyloid toxicity associated with Alzheimer's disease (AD). Such p3-membrane interactions are considered to induce the disruption of membrane permeability and integrity, but the exact mechanisms of how p3 aggregates, particularly small p3 oligomers, induce receptor-independent membrane disruption are not yet completely understood. Here, we investigate the adsorption, orientation, and surface… CONTINUE READING
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