Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro

@article{Li1999MolecularIB,
  title={Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro},
  author={He Xiao Li and Ying Alisa Cao and Michael C. Berndt and John W. Funder and Jun-Ping Liu},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={6785-6794}
}
The telomere DNA polymerase (telomerase) and the tumor suppressor protein p53 are frequently associated with human cancers, and activation of telomerase and inactivation of p53 involved in cancer cell immortalization. In this report, we demonstrate a direct interaction of telomerase with p53 in the nuclear lysates of human breast cancer cells, and with recombinant human p53, by affinity chromatography and immunoprecipitation. On activity criteria, the interaction is between the carboxyl… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Telomeres-structure, function, and regulation.

  • Experimental cell research
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND