Molecular interactions between neurotrophin receptors

  title={Molecular interactions between neurotrophin receptors},
  author={Georg Dechant},
  journal={Cell and Tissue Research},
Neurotrophins signal via a dual-receptor system comprising receptor tyrosine kinases, the Trks, and a tumor necrosis factor (TNF) receptor like molecule, p75. Interest in these receptors was spurred on by the finding that they are employed by their neurotrophin ligands to activate opposing cellular mechanisms. Signalling via Trk receptors promotes the survival of embryonic neurons, whereas activation of p75 can trigger apoptosis. However, this antagonistic view is an oversimplification. It is… CONTINUE READING


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