Molecular interactions between albumin and proximal tubular cells.

  title={Molecular interactions between albumin and proximal tubular cells.},
  author={Nigel John Brunskill},
  journal={Experimental nephrology},
  volume={6 6},
In glomerular diseases the filtration of excess proteins into the proximal tubule, together with their subsequent reabsorption may represent an important pathological mechanism underlying progressive renal scarring. The most prominent protein in glomerular filtrate, albumin, is reabsorbed by receptor-mediated endocytosis by proximal tubular cells. It binds both to scavenger-type receptors and to megalin in the proximal tubule. Some of these receptors appear to be shared with other cell types… CONTINUE READING