Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

@inproceedings{Wallerman2009MolecularIB,
  title={Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing},
  author={Ola Wallerman and Mehdi Motallebipour and Stefan Enroth and Kalicharan Patra and Madhu Sudhan Reddy Bysani and Jan Komorowski and Claes Wadelius},
  booktitle={Nucleic acids research},
  year={2009}
}
Gene expression is regulated by combinations of transcription factors, which can be mapped to regulatory elements on a genome-wide scale using ChIP experiments. In a previous ChIP-chip study of USF1 and USF2 we found evidence also of binding of GABP, FOXA2 and HNF4a within the enriched regions. Here, we have applied ChIP-seq for these transcription factors and identified 3064 peaks of enrichment for GABP, 7266 for FOXA2 and 18783 for HNF4a. Distal elements with USF2 signal was frequently bound… CONTINUE READING
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