Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis.

@article{Fuxe2010MolecularIV,
  title={Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis.},
  author={Kjell Fuxe and Daniel Marcellino and Giuseppina Leo and Luigi Francesco Agnati},
  journal={Current opinion in pharmacology},
  year={2010},
  volume={10 1},
  pages={14-22}
}
The intramembrane receptor-receptor interactions among GPCRs demonstrated in the beginning of the 80s in the CNS probably reflect the existence of allosteric mechanisms in receptor heteromers, and the postulated assemblies of multiple GPCRs coined 'receptor mosaics' in the early 80s probably represent higher order receptor heteromers, recently demonstrated with novel biophysical techniques in living cells. The receptor interface in the GPCR heteromers is beginning to be characterized and in… CONTINUE READING

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Relevance of receptor topology and allosteric modulators for the integrative functions of receptor mosaics

  • L Agnati, D Guidolin, +5 authors K Fuxe
  • J Receptor Signal Transduct Res
  • 2009
Highly Influential
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