Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development.

Abstract

The development of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals that establish the proximo-distal (PD) axis by activating target genes such as Distalless (Dll). Dll expression in the leg depends on a Dpp- and Wg-dependent phase and a maintenance phase that is independent of these signals. Here, we show that accurate… (More)
DOI: 10.1016/j.devcel.2007.11.002

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