Molecular insights into the recruitment of TFIIH to sites of DNA damage.

@article{Oksenych2009MolecularII,
  title={Molecular insights into the recruitment of TFIIH to sites of DNA damage.},
  author={Valentyn Oksenych and Bruno Bernardes de Jesus and Alexander Zhovmer and Jean-Marc Egly and Fr{\'e}d{\'e}ric Coin},
  journal={The EMBO journal},
  year={2009},
  volume={28 19},
  pages={
          2971-80
        }
}
XPB and XPD subunits of TFIIH are central genome caretakers involved in nucleotide excision repair (NER), although their respective role within this DNA repair pathway remains difficult to delineate. To obtain insight into the function of XPB and XPD, we studied cell lines expressing XPB or XPD ATPase-deficient complexes. We show the involvement of XPB, but not XPD, in the accumulation of TFIIH to sites of DNA damage. Recruitment of TFIIH occurs independently of the helicase activity of XPB… CONTINUE READING
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Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC

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