Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.

@article{Goetz2007MolecularII,
  title={Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.},
  author={Regina M Goetz and Andrew Beenken and Omar A. Ibrahimi and Juliya Kalinina and Shaun K. Olsen and Anna V Eliseenkova and Chongfeng Xu and Thomas A Neubert and Fuming Zhang and Robert J. Linhardt and Xijie Yu and Kenneth E. White and Takeshi Inagaki and Steven A. Kliewer and Masaya Yamamoto and Hiroshi Kurosu and Yasushi Ogawa and Makoto Kuro-O and Beate Lanske and Mohammed Shawkat Razzaque and Moosa Mohammadi},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 9},
  pages={3417-28}
}
Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. These FGFs require the presence of Klotho/betaKlotho in their target tissues. Here, we present the crystal structures of FGF19 alone and FGF23 in complex with sucrose octasulfate, a disaccharide chemically related to heparin. The conformation of the heparin-binding region between beta strands 10 and 12 in FGF19 and… CONTINUE READING
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