Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting.

@article{Antunes2014MolecularII,
  title={Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting.},
  author={Diana Antunes and Ana Isabel Padr{\~a}o and Elisabete A Maciel and Deolinda Santinha and Paula Alexandra Oliveira and Rui Vitorino and Daniel Moreira-Gonçalves and Bruno Jorge Colaço and Maria Jo{\~a}o Pires and Cl{\'a}udia Nunes and L{\'u}cio Lara Santos and Francisco Manuel Lemos Amado and Jos{\'e} Alberto Duarte and M Ros{\'a}rio M Domingues and Rita Pinho Ferreira},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1841 6},
  pages={896-905}
}
Alterations in muscle mitochondrial bioenergetics during cancer cachexia were previously suggested; however, the underlying mechanisms are not known. So, the goal of this study was to evaluate mitochondrial phospholipid remodeling in cancer-related muscle wasting and its repercussions to respiratory chain activity and fiber susceptibility to apoptosis. An animal model of urothelial carcinoma induced by exposition to N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) and characterized by significant… CONTINUE READING
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Lipidomic analysis of isolated mitochondria revealed a significant decrease of phosphatidic acid , phosphatidylglycerol and cardiolipin in BBN mitochondria , counteracted by increased phosphatidylcholine levels .
Lipidomic analysis of isolated mitochondria revealed a significant decrease of phosphatidic acid , phosphatidylglycerol and cardiolipin in BBN mitochondria , counteracted by increased phosphatidylcholine levels .
Lipidomic analysis of isolated mitochondria revealed a significant decrease of phosphatidic acid , phosphatidylglycerol and cardiolipin in BBN mitochondria , counteracted by increased phosphatidylcholine levels .
Lipidomic analysis of isolated mitochondria revealed a significant decrease of phosphatidic acid , phosphatidylglycerol and cardiolipin in BBN mitochondria , counteracted by increased phosphatidylcholine levels .
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