Molecular insights into Down syndrome-associated leukemia.

  title={Molecular insights into Down syndrome-associated leukemia.},
  author={Paresh Vyas and John D. Crispino},
  journal={Current opinion in pediatrics},
  volume={19 1},
PURPOSE OF REVIEW Four years ago it was discovered that nearly all cases of transient myeloproliferative disorder and acute megakaryocytic leukemia in children with Down syndrome acquire mutations in the hematopoietic transcription factor gene GATA1. Studies within the past year, described within this review, have provided tremendous insights into the role of GATA1 mutations in these malignancies. RECENT FINDINGS In the past year, our understanding of the molecular and cellular consequences… CONTINUE READING
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