Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.

@article{Gong2014MolecularII,
  title={Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.},
  author={Bei Gong and Minsang Shin and Jiali Sun and Chai Teck Jung and Edward L. Bolt and John van der Oost and Jeong Sun Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 46},
  pages={
          16359-64
        }
}
Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a "Cascade" ribonucleoprotein complex to guide RNA specifically to complementary sequence in invader double-stranded DNA (dsDNA), a process called "interference." After target recognition by Cascade, formation of an R-loop triggers recruitment of a Cas3 nuclease-helicase, completing the… CONTINUE READING
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