Molecular insight into the inhibition mechanism of plant and rat 4-hydroxyphenylpyruvate dioxygenase by molecular docking and DFT calculations

@article{Silva2015MolecularII,
  title={Molecular insight into the inhibition mechanism of plant and rat 4-hydroxyphenylpyruvate dioxygenase by molecular docking and DFT calculations},
  author={Telles Cardoso Silva and Ma{\'i}ra dos Santos Pires and Alexandre de Castro and Elisabete da Cunha and Melissa Soares Caetano and Teodorico Castro Ramalho},
  journal={Medicinal Chemistry Research},
  year={2015},
  volume={24},
  pages={3958-3971}
}
The 4-hydroxyphenylpyruvate dioxygenase (HPPD) is a relevant target protein for therapeutic and agrochemical research. It is an iron-dependent enzyme, and its inhibition has very different effects on plants and animals. In animals, the enzyme has an important role in the catabolism of tyrosine, and in the plant, it operates in the cascade of photosynthesis. Potent HPPD inhibitors have been described, and all contain the 1,3-diketone group in its shape. In this research, we carried out a study… CONTINUE READING

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