Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.

@article{Maudet2011MolecularII,
  title={Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.},
  author={Claire Maudet and Matthieu Bertrand and Erwann Le Rouzic and Hichem Lahouassa and Diana Ayinde and S{\'e}bastien Nisole and Caroline Goujon and Andrea Cimarelli and Florence Margottin-Goguet and Catherine Transy},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 27},
  pages={23742-52}
}
Vpr, a small HIV auxiliary protein, hijacks the CUL4 ubiquitin ligase through DCAF1 to inactivate an unknown cellular target, leading to cell cycle arrest at the G(2) phase and cell death. Here we first sought to delineate the Vpr determinants involved in the binding to DCAF1 and to the target. On the one hand, the three α-helices of Vpr are necessary and sufficient for binding to DCAF1; on the other hand, nonlinear determinants in Vpr are required for binding to the target, as shown by using… CONTINUE READING
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