Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach

@article{Jaiswal2015MolecularIO,
  title={Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach},
  author={A. Jaiswal and P. T. Lakshmi},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2015},
  volume={33},
  pages={1442 - 1459}
}
  • A. Jaiswal, P. T. Lakshmi
  • Published 2015
  • Biology, Medicine
  • Journal of Biomolecular Structure and Dynamics
  • Telomere holds special mechanism for solving end repair problems and maintaining genomic stability. Protection of telomeres 1 (POT1) which belongs to shelterin family is identified as a key protein that recruits telomerase by interacting with telomere repeat binding factors (TRB1-3). Since, deciphering the mechanism through which POT assembles telomerase is of great interest, computational approaches have been undertaken to understand the mechanism in a well- developed model system… CONTINUE READING
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    References

    SHOWING 1-10 OF 69 REFERENCES
    AtTRB1–3 Mediates Structural Changes in AtPOT1b to Hold ssDNA
    • 1
    • Highly Influential
    • PDF
    Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase
    • 102
    • PDF
    Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In Vitro
    • 209
    • PDF
    Caenorhabditis elegans POT-1 and POT-2 Repress Telomere Maintenance Pathways
    • 16
    • PDF
    Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase
    • 41
    • Highly Influential
    Dyskerin Is a Component of the Arabidopsis Telomerase RNP Required for Telomere Maintenance
    • 64
    • PDF
    Pot1 and cell cycle progression cooperate in telomere length regulation
    • 74
    Interactions of putative telomere‐binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants
    • 56
    • PDF
    The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection
    • 125
    • PDF
    Comparative biology of telomeres: Where plants stand
    • 76