Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach

@article{Jaiswal2015MolecularIO,
  title={Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach},
  author={A. Jaiswal and P. Lakshmi},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2015},
  volume={33},
  pages={1442 - 1459}
}
Telomere holds special mechanism for solving end repair problems and maintaining genomic stability. Protection of telomeres 1 (POT1) which belongs to shelterin family is identified as a key protein that recruits telomerase by interacting with telomere repeat binding factors (TRB1-3). Since, deciphering the mechanism through which POT assembles telomerase is of great interest, computational approaches have been undertaken to understand the mechanism in a well- developed model system… Expand
3 Citations
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TLDR
An attempt has been made to elucidate the reason behind the interaction by analyzing molecular docking interaction between AtPOT1b and AtTRB1–3, which yielded potential residues, which could play essential role in structural modification of TRB1-3. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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