Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach

  title={Molecular inhibition of telomerase recruitment using designer peptides: an in silico approach},
  author={A. Jaiswal and P. T. Lakshmi},
  journal={Journal of Biomolecular Structure and Dynamics},
  pages={1442 - 1459}
  • A. Jaiswal, P. T. Lakshmi
  • Published 2015
  • Biology, Medicine
  • Journal of Biomolecular Structure and Dynamics
  • Telomere holds special mechanism for solving end repair problems and maintaining genomic stability. Protection of telomeres 1 (POT1) which belongs to shelterin family is identified as a key protein that recruits telomerase by interacting with telomere repeat binding factors (TRB1-3). Since, deciphering the mechanism through which POT assembles telomerase is of great interest, computational approaches have been undertaken to understand the mechanism in a well- developed model system… CONTINUE READING
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