Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus

@article{BirdLieberman2012MolecularIU,
  title={Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus},
  author={Elizabeth Louise Bird-Lieberman and Andr{\'e} A Neves and Pierre P Lao-Sirieix and Maria O'Donovan and Marco Novelli and Laurence B. Lovat and William S. Eng and Lara K Mahal and Kevin M Brindle and Rebecca C Fitzgerald},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={315-321}
}
Barrett's esophagus is an example of a pre-invasive state, for which current endoscopic surveillance methods to detect dysplasia are time consuming and inadequate. The prognosis of cancer arising in Barrett's esophagus is improved by early detection at the stage of mucosal carcinoma or high-grade dysplasia. Molecular imaging methods could revolutionize the detection of dysplasia, provided they permit a wide field of view and highlight abnormalities in real time. We show here that cell-surface… CONTINUE READING
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