Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes.

Abstract

Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxicity based mainly on in vitro studies. To better understand… (More)
DOI: 10.1016/j.freeradbiomed.2017.12.034

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Cite this paper

@article{Kishimoto2017MolecularIO, title={Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes.}, author={Shun Kishimoto and Nobu Oshima and Kazutoshi Yamamoto and Jeeva P. Munasinghe and Jan H. Ardenkjx00E6r-Larsen and J Brian A Mitchell and Peter L. Choyke and Murali C. Krishna}, journal={Free radical biology & medicine}, year={2017}, volume={116}, pages={1-10} }